TAT and pulmonary arterial hypertension: The authors identified two lncRNAs in modulating smooth muscle cell proliferation (ncRNA ENST00000495536 associated the HOXB13 gene expression and lncRNA ENST00000585387, a ceRNA for miRNAs, miR-491 and miR-185) [46] and found that, when these lncRNAs were silenced using siRNA, the effects of cocaine and Tat treatment on cell proliferation were lost, suggesting that these lncRNAs may play a role in the development of PAH in HIV-1-positive individuals [46].