Here, we describe the generation and characterization of two novel vaccine candidates against AD based on the MVA vector expressing either the human full-length 4R2N tau isoform protein or a 3RC tau protein containing 3 tubulin-binding motifs and the C-terminal region (termed MVA-Tau4R2N and MVA-Tau3RC, respectively). The gene discussed is MAPT; the disease is Alzheimer disease.