PPARGC1A and dry age related macular degeneration: Once nuclear factor erythroid 2-related factor 2 (NFE2L2) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) genes are silenced, it is possible to detect evidence of oxidative stress, protein aggregation and mitochondrial damage resembling the clinical signs of dry AMD [16,17].