LRP1 and Alzheimer disease: In an autopsy of AD brains, the levels of 4-HNE bound to transmembrane LRP-1 had significantly increased in the hippocampus, while the levels of LRP-1-3-nitrotyrosine had not, suggesting that Aβ impaired its own efflux from the brain by oxidation of its transporter LRP-1, leading to increased Aβ deposition [70].