Furthermore, we investigated expressive changes of two main Aβ transport receptors, LRP-1 and RAGE, and revealed that CCH increased LRP-1 and RAGE expression in brain parenchyma, while a decrease of LRP1 and increase of RAGE were observed in vascular endothelial cells, suggesting double imbalances of Aβ efflux and influx transport-related proteins in the cortical blood vessel of AD mice. This evidence concerns the gene LRP1 and Alzheimer disease.