We revealed that neural oxidative stress and neuroinflammation were enhanced in AD model mice with CCH and that edaravone, a free radical scavenger, significantly improved motor and cognitive deficits, attenuated neuronal loss, reduced Aβ/phosphorylated tau (pTau) accumulation and alleviated neural oxidative stress and neuroinflammation in the AD mouse model with CCH [85]. This evidence concerns the gene MAPT and Cognitive impairment.