For instance, in some human colon cancer cell lines (SW480 and RKO cells) CSE is expressed and its silencing or its pharmacological inhibition suppresses cell proliferation and migration [43], while in other colon cancer lines (e.g., HCT116), CSE is also expressed, but its silencing does not affect cell proliferation or bioenergetics [24]. This evidence concerns the gene CTH and malignant colon neoplasm.