CBS and malignant colon neoplasm: Likewise, in many human colon cancer cell lines, CBS was found to be highly expressed, and genetic silencing or pharmacological inhibition of CBS exerted antitumor effects in vitro and in vivo [24,25,26,37,38,39,40,41] while forced expression of CBS into non-transformed human epithelial cells increased their growth in situ (but did not render them metastatic) [42].