Dual roles have been observed in other lncRNAs; for instance, HOXA11-AS, which is up-regulated (e.g., breast cancer, osteosarcoma, glioma, hepatocarcinoma), but down-regulated (glioblastoma, colorectal cancer, and ovarian cancer) in several types of cancer [39]. This evidence concerns the gene HOXA11 and glioblastoma.