On the other hand, H2S-releasing NaHS accelerated gastric ulcer healing but in contrast with CO-releasing CORM-2, this effect of H2S donor was accompanied by the upregulation of gastric mucosal protein expression for Nrf-2, vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFr) at the ulcer margin [42,53]. The gene discussed is EGFR; the disease is gastric ulcer.