Nevertheless, it has been demonstrated that 5-phosphatases, such as Src homology 2-containing inositol 5-phosphatase (SHIP) in hematopoietic cells [8], Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase (PIB5PA) in neuritis and melanoma cells [9,10], and Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) in glioblastoma and GC cells, inhibit Akt activation [11,12]. Here, INPP5D is linked to melanoma.