SHIP2, encoded by inositol polyphosphate phosphatase-like 1 (INPPL1), belongs to the phosphoinositide 5-phosphatase family, which has been implicated in some human diseases such as type 2 diabetes, Alzheimer’s disease and Opsismodysplasia [13,14,15]. This evidence concerns the gene INPPL1 and early-onset autosomal dominant Alzheimer disease.