IQGAP2 and gastric cancer: Next, to confirm that the interaction of IQGAP2 with SHIP2 is required for the inhibitory effect of IQGAP2 on GC cells migration and invasion, we knocked down IQGAP2 in ectopic SHIP2-overexpressing GC cells, and found that IQGAP2 knockdown reversed the inhibition of cell migration and invasion by SHIP2 induction.