In a further study, to address whether the binding of IQGAP2 to PRD and SAM domains of SHIP2 participated in the inhibitory effects of IQGAP2 on the migration and invasion of GC cells, we introduced wild-type SHIP2 or deletion mutant SHIP2△935-1258 plasmids into SGC-7901.sh-SHIP2 stable cell lines. This evidence concerns the gene INPPL1 and gastric cancer.