Pharmacodynamic analysis on tumors treated with drugs as single agents or a combination at the same doses used in the activity, showed a slight increase of caspase-3 activation in tumor protein extracts from mice treated with the combination (Figure 5C) and a slight increase of the mitotic marker phospho-histone H3 and γH2AX after both paclitaxel and combined treatments (Figure 5D). The gene discussed is CASP3; the disease is neoplasm.