MTOR and skin basal cell carcinoma: In order to determine the mechanism by which Metf improved the response to PDT in the BCC cell lines, we analyzed the expression of the AMPK/mTOR pathway proteins by WB: control; 24 h after 75μM Metf; 24 h after PDT treatment (5-h incubation with MAL and 7.6 J/cm2 in ASZ and 3.8 J/cm2 in CSZ cells); and combination of Metf and MAL-PDT (Figure 5b).