Interestingly, exome sequencing recently identified two somatic mutations, i.e., USP8 and USP48, which occurred with far greater frequency in corticotrope adenomas from women with Cushing’s disease [10,11], thus indicating that the corticotrope adenoma itself may harbour features which contribute to gender-dependent differences in Cushing’s disease. This evidence concerns the gene USP48 and ACTH-producing pituitary gland adenoma.