Patients with type 1 diabetes whose circulating TNFR2 levels were in the highest quartile had a 55% cumulative incidence of reaching stage 3 CKD, whereas those with TNFR2 levels in the lower three quartiles had a 15% cumulative incidence after 12 years of follow-up in the early stages of DKD (normal renal function and normo- or microalbuminuria). The gene discussed is TNFRSF1B; the disease is chronic kidney disease.