Moreover, profound immunosuppression occurs in the tumor microenvironment, particularly in the context of cell-mediated immunity [31], which is driven by an array of cytokines, such as prostaglandin E2, transforming growth factor beta (TGF-β), matrix metallopeptidase 9, IL-10, programmed death-ligand 1 (PD-L1), granulocyte colony stimulating factor, VEGF, and S100A4 [18,31,33,52,53]. This evidence concerns the gene CD274 and neoplasm.