In a mouse model of glioma, a monocytic population of MDSCs (CD11b+Gr1low) has been found to infiltrate more than the granulocytic (CD11b+Gr1high) MDSCs, which could simultaneously express the marker of pro-inflammatory M1 and tumor-supportive M2 macrophages [17,96,97,98]. Here, ITGAM is linked to central nervous system cancer.