NOS2 and acute myocardial infarction: Previously, dabigatran was found to significantly enhance catalase and superoxide dismutase activity and suppress inducible nitric oxide synthase (iNOS) in a rabbit model of acute myocardial infarction (AMI); the AMI was induced by an intravenous bolus (0.5 mg/kg) and concomitant infusion (0.15 mg/kg/h) [15].