These IHC tests are fundamental to identify cHL cells (expressing CD15 and CD30 and are CD45 negative in a vast majority of cases, with variable positivity for CD20) from the nodular lymphocyte predominant subtype (staining positively for CD20 and CD45 whilst CD15 and CD30 negative). The gene discussed is TNFRSF8; the disease is classic Hodgkin lymphoma.