However, we observed that two genetic variants, rs1521 and rs3094228, associated with Graves’ disease and TPOAb-positivity, respectively, fall in the gene regulatory regions of MIC-A and MIC-B genes, two ligands of CD314 (NKG2D), and alter their gene expressions in thyroid cells [32,33,34,60,61,62] (Figure 3, Table S4, Figure S2). Here, KLRK1 is linked to Graves disease.