CASP2 and hypothyroidism: However, when participants were divided into 4 categories according to TSH and TPOAb levels (Figure 4c), reflecting different clinical categories (hyperthyroidism, euthyroidism/TPOAb-negative, hypothyroidism and euthyroidism/TPOAb-positive), Caspase-2 showed significantly higher mean and variance in two groups: hypothyroidism and euthyroidism/TPOAb-positive (Figure 4d).