However, four genetic variants associated with thyroid phenotypes published in the GWAS catalog (rs3761959, rs7528684, rs505922, and rs3184504) were also associated in cis and trans with nine circulating protein abundances (BGAT, CHSTB, DC-SIGN, Desmoglein-2, DYR, FCRL3, GP1BA, MBL, and VCAM-1) (Table S7). The gene discussed is DHFR; the disease is thyroid gland disorder.