In contrast, experimental studies in mice have shown that an increase in omega-3 DHA-derived 19,20-epoxydocosapentaenoic acid (19,20-EDP) in plasma and tumor obtained by adding a low dose of sEH inhibitors is associated with a decrease in tumor growth by inhibition of tumor angiogenesis and reduced cell invasion [24]. Here, EPHX2 is linked to neoplasm.