A study investigating mRNA expression levels of the TRP channels in human CRC tissue versus normal colon mucosa detected an increase in gene expression of TRPM8, TRPV6, and TRPV1 and a lower expression of TRPV4, TRPM4, TRPV3, TRPC6, and TRPV5 in the tumor tissues of CRC compared to normal tissues [119]. This evidence concerns the gene TRPV4 and neoplasm.