In different solid cancers, we and other groups have identified a distinct circulating cancer-associated cell that is large, polymorphic in shape, often polynuclear (≥1 DAPI+ nucleus), with a dual epithelial and macrophage/myeloid phenotype (dual CK+/EpCAM+ and CD14/CD45+) (Table 2) [5,27,28,73,74]. Here, EPCAM is linked to cancer.