AKT1 and breast neoplasm: Hybrids formed between human breast tumor cells MCF-7 were heterogeneous with regard to chemoresistance to doxorubicin [89]; however, hybrids derived from MDA-MB-435 and breast epithelial cells showed altered sensitivity to the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002, as a consequence of differential Rapidly Accelerated Fibrosarcoma-Akt (RAF-AKT) crosstalk between hybrid cells [90].