GATM and stroke disorder: In this work, we demonstrate that: (1) eight validated genes are differentially expressed in AGAT-/- compared with WT mice; (2) altered Bcas1 and Slc6a8 expression is creatine-dependent; (3) Kcnip3 and Ivd expression levels are hArg-dependent; and (4) expression of Bcas1 and Slc6a8 is increased after stroke.