KCNIP3, also known as calsenilin, is a neuronal calcium-binding protein that has been shown to have multiple functions in the cells, including regulating the intracellular concentration of calcium, the binding and modulation of the Alzheimer’s-disease-related protein presenilin and controlling of multiple signaling pathways as a second messenger [24,25]. This evidence concerns the gene NECAB1 and glycogen storage disease VI.