The canonical pathways observed for this cluster were cyclins and cell cycle regulation, cell cycle G1/S checkpoint, glioma, p53 signaling pathway, melanoma and Wnt signaling pathway enriched with EGFR, CCNE1, FZD9, CDKN2A, SFRP1, CDK6, SERPINB5, FGF9, MMP7, CALML5, TCF7L1, SHC4, and PRKX genes. This evidence concerns the gene TCF7L1 and melanoma.