The canonical pathways observed for this cluster were cyclins and cell cycle regulation, cell cycle G1/S checkpoint, glioma, p53 signaling pathway, melanoma and Wnt signaling pathway enriched with EGFR, CCNE1, FZD9, CDKN2A, SFRP1, CDK6, SERPINB5, FGF9, MMP7, CALML5, TCF7L1, SHC4, and PRKX genes. Here, CDKN2A is linked to central nervous system cancer.