The canonical pathways observed for this cluster were cyclins and cell cycle regulation, cell cycle G1/S checkpoint, glioma, p53 signaling pathway, melanoma and Wnt signaling pathway enriched with EGFR, CCNE1, FZD9, CDKN2A, SFRP1, CDK6, SERPINB5, FGF9, MMP7, CALML5, TCF7L1, SHC4, and PRKX genes. The gene discussed is SHC4; the disease is melanoma.