The SUZ12 and EED mutations identified thus far do not appear to cluster at any known conserved domains within either gene, such as the VEFS binding domain of SUZ12 or the WD40 protein interaction domain of EED, but this may be due to the limited number of MPNST samples that have been characterized for their PRC2 mutant status. Here, SUZ12 is linked to malignant peripheral nerve sheath tumor.