BAX and colon carcinoma: We also found that EPS inhibited the growth, and induced apoptosis, of undifferentiated hiPSCs by inducing G2/M cell cycle arrest, loss of MMP, activation of caspases, and an increase in the Bax to Bcl-xL ratio (Figure 1, Figure 2, Figure 3 and Figure 4), as also observed in EPS-induced apoptosis of cancer cells, including HT-29 human colon carcinoma cells, A549 human lung cancer cells, and MCF-5 human breast carcinoma cells.