We found that the proportions of CD4+ TN were slightly increased in the blood of HCC patients as compared to healthy controls (18.06 ± 5.21 vs. 14.24 ± 5.80), and TCM were decreased (10.24 ± 1.84 vs. 15.36 ± 6.87 in controls) (Table 4 and Figure 3c), whereas the proportions of TEM and effector cells TEFF were similar. Here, CD4 is linked to hepatocellular carcinoma.