Interestingly, the percentage of T cells that express PD-1 is significantly increased in the peritumor (14.98 ± 4.14 for CD4+ T cells and 14.24 ± 4.82 for CD8+ T cells), and even more at tumor site (18.3 ± 5.2 for CD4+ T cells and 17.07 ± 6.59 for CD8+ T cells) (Figure 4c and Table 5), and the intensity of the expression is also significantly increased on both T cells in the tumor as compared to the PBMC of the same patients and to those of healthy donors (Figure 4d and Table 5). Here, CD8A is linked to neoplasm.