CD8A and hepatocellular carcinoma: When we look at these subsets within CD8+ T cells, we observe that while TN in the PBMC of HCC patients (19.47 ± 4.99) were similar to those of healthy donors (19.90 ± 8.58) (Table 4 and Figure 3d), and both TCM (4.62 ± 2.10) and TEM (28.98 ± 4.64) were decreased as compared to controls (9.36 ± 4.39 and 40.31 ± 9.17, respectively).