Interestingly, the percentage of T cells that express PD-1 is significantly increased in the peritumor (14.98 ± 4.14 for CD4+ T cells and 14.24 ± 4.82 for CD8+ T cells), and even more at tumor site (18.3 ± 5.2 for CD4+ T cells and 17.07 ± 6.59 for CD8+ T cells) (Figure 4c and Table 5), and the intensity of the expression is also significantly increased on both T cells in the tumor as compared to the PBMC of the same patients and to those of healthy donors (Figure 4d and Table 5). This evidence concerns the gene CD4 and neoplasm.