LmnaG609G/G609G mice, which express ubiquously progerin and lamin C and lack lamin A, recapitulate the main clinical manifestations of human HGPS, such as difficulty to thrive, lipodystrophy, skeleton abnormalities, vascular calcification and stiffening, vascular smooth muscle cell (VSMC) loss, and premature death [23,24,25]. The gene discussed is LMNA; the disease is lipodystrophy.