LMNA and Hutchinson-Gilford progeria syndrome: LmnaG609G/G609G mice, which express ubiquously progerin and lamin C and lack lamin A, recapitulate the main clinical manifestations of human HGPS, such as difficulty to thrive, lipodystrophy, skeleton abnormalities, vascular calcification and stiffening, vascular smooth muscle cell (VSMC) loss, and premature death [23,24,25].