Nevertheless, these models have been a useful tool to investigate, among others, the oncogenic role of PML-RARA fusion and of its reciprocal [37,44,52], the co-existing events to the t(15;17) [53], the immune modulation of APL [54,55], and the mechanisms of response to therapy [56,57,58]. This evidence concerns the gene PML and acute promyelocytic leukemia.