It has been found that alterations in FLT3-ITD impedes retinoic acid, but no arsenic, responses in a murine model [132], and that ATRA and ATO selectively exert synergistic cytotoxicity against FLT3-ITD AML cells via co-inhibition of FLT3 signaling pathway [133,134]. Here, FLT3 is linked to acute myeloid leukemia.