To examine whether reported alterations in the proportion of particular serum FA groups in CKD had an impact on adipose leptin gene expression, we treated 3T3-L1 adipocytes with a selected representative SFA (palmitic acid 16:0, PA), MUFA (oleic acid 18:1, OA), n-3 PUFA (docosahexaenoic acid 22:6 n-3, DHA), and n-6 PUFA (arachidonic acid 20:4 n-6, AA). This evidence concerns the gene LEP and chronic kidney disease.