The physiologic relevance of this relationship was also observed in SLE patients, where TACE activity levels were higher in the high sLOX-1 groups (low sLOX-1 mean = 60.4 ± 4.409, n = 167, high sLOX-1 mean = 79.75 ± 3.851, n = 101) and correlated significantly with sLOX-1 levels (rs = 0.422, p = 3.01e-13) (Fig 5G and S2 Table). Here, ADAM17 is linked to systemic lupus erythematosus.