Furthermore, when three human tauopathy MAPT variants are expressed under the control of the mouse α‐tubulin promoter, in the absence of endogenous Mapt, coiled bodies form inside spinal cord oligodendrocytes, and oligodendrocyte number is reduced by 6 months of age—prior to neuron loss (Higuchi et al., 2002). The gene discussed is MAPT; the disease is tauopathy.