As oligodendrocytes express tau (Cullen et al., 2019; Young et al., 2013), it is possible that oligodendrocytes undergo apopotosis due to a direct effect of hyperphosphorylated tau; however, in the Prnp‐MAPTP301L and MAPTP301S mouse models of tauopathy, oligodendrocyte death is more likely a secondary consequence of tauopathy, as the expression of hyperphosphorylated tau is directed by the prion protein promotor in both instances. Here, PRNP is linked to tauopathy.