MAPT and Cognitive impairment: Transgenic mice that express human tauopathy‐associated variants in MAPT, primarily the MAPTP301L and MAPTP301S variants, also recapitulate many of the aspects of human tauopathy, including the development of gliosis, the formation of neurofibrillary tangles, neuron loss, and motor and cognitive impairment (Lewis et al., 2000; Lin, Lewis, Yen, Hutton, & Dickson, 2003a, 2003b; Ramsden et al., 2005; Ren et al., 2014; Santacruz et al., 2005; Takeuchi et al., 2011; Yoshiyama et al., 2007).