KEGG pathway analysis also showed that the neighbor genes of WNT5A were widely distributed in multiple pathways in the de novo pathways of glioma occurrence, in which crucial oncogenes (EGFR and MDM2) and 2 important tumor suppressors (PTEN and IKN4a/ARF) were closely correlated with WNT5A. Here, WNT5A is linked to central nervous system cancer.