KEGG pathway analysis also showed that the neighbor genes of WNT5A were widely distributed in multiple pathways in the de novo pathways of glioma occurrence, in which crucial oncogenes (EGFR and MDM2) and 2 important tumor suppressors (PTEN and IKN4a/ARF) were closely correlated with WNT5A. This evidence concerns the gene MDM2 and central nervous system cancer.