Analyzing the mRNA data of 19 WNTs from TCGA and CGGA database, we found that WNT5A mRNA expression level was significantly correlated with the grade of glioma in both TCGA and CGGA databases (Figure 5A); however, WNT10B expression was inversely correlated with the grade of glioma (Figure 5B). This evidence concerns the gene WNT5A and central nervous system cancer.