In quartile (Q) 1, the ARMS2 A69S TT genotype was found in 13.5% of subjects and was associated with increased odds of early AMD (OR, 2.35; 95% CI: 1.29-4.29), whereas the CFH I62V CT and TT genotypes were found in 50.8% and 16.7% of subjects, respectively, and were also associated with increased risk (OR, 1.82 and 2.08, respectively; 95% CI: 1.07-3.10 and 1.08-4.03, respectively). This evidence concerns the gene ARMS2 and age-related macular degeneration.