According to these results, we identified an 8-mRNA signature to evaluate the overall survival time of PAAD patients based on the expression of the 8 mRNAs and their regression coefficients as follows: Risk score = (-0.01579 × expression level of ADH1B) + (0.07838 × expression level of CA9) + (-0.76361 × expression level of CDHR3) + (0.33812 × expression level of CXCL9) + (-0.06606 × expression level of GIMAP7) + (-0.70384 × expression level of ICAM3) + (-0.11457 × expression level of LDLRAD1) + (-0.24179 × expression level of P2RY8). The gene discussed is P2RY8; the disease is pancreatic adenocarcinoma.