In contrast, the examination of the correlation between FOXO1 with these three genes indicated that repressing the level of CA9 increased the protein and mRNA levels of FOXO1 in PAAD cells (Figure 6D), whereas, the inhibition of CXCL9 or GIMAP7 by siRNA down-regulated the levels of FOXO1 in PANC-1 and SW 1990 cells (Figure 6E and 6F). This evidence concerns the gene FOXO1 and pancreatic adenocarcinoma.