We next examined the downstream inflammatory factors of FOXO1, such as IL-8, IL-10, VEGF, and PD-L1 [20–23] and found that knocking down CA9 significantly decreased the mRNA levels of IL-8, IL-10, VEGF, and PD-L1, but the knockdown of CXCL9 and GIMAP7 substantially increased IL-8, IL-10, VEGF, and PD-L1 expression levels in PAAD cells (Figure 6H and Supplementary Figure 1F). Here, FOXO1 is linked to pancreatic adenocarcinoma.