TPO and autoimmune thrombocytopenic purpura: First-line treatments for children with ITP include corticosteroids, intravenous immunoglobulin, and anti-D immunoglobulin, whereas second-line treatment options are rituximab, splenectomy, and more recently the thrombopoietin receptor agonists (TPO-RA) eltrombopag (EPAG) and romiplostim [5].