This integrative methodology was used to support the approval of EGFR-TKIs (gefitinib, Iressa, AstraZeneca; erlotinib, Tarceva, Genentech/Astellas) as first-line treatment for patients with advanced NSCLC harboring somatic mutations in EGFR exons 19 and 21. This evidence concerns the gene EGFR and non-small cell lung carcinoma.