IL4 and amyloidosis: These results confirm previous findings in this animal model (Donovan et al., 2006; He et al., 2013; Heneka et al., 2013; McClean and Holscher, 2014; Unger et al., 2016) and indicate that 12-month-old mice can be used to investigate the role of IL4/STAT6 signaling in the astroglia of diseased brain that manifests amyloid pathology.