Indeed, iDCs can mediate trans-infection through the interaction of several proteins belonging to the C-type lectin receptor (CLRs) family [such as DC-SIGN, mannose receptor (MR) (also known as CD206), langerin (CD207), and syndecan-3] with HIV-1 GP120 protein (Kijewski and Gummuluru, 2015). This evidence concerns the gene LARS1 and infection.