As it has been shown that human DCs are relatively resistant to innate sensing, due to a blockade of HIV-1 viral RNA reverse transcription by SAMHD1, hence of HIV-1 infection, all processes of HIV-1 transfer could happen with minimal stimulation of the innate system, making DCs as the perfect trojan horses for HIV-1 (Antonucci et al., 2017). The gene discussed is SAMHD1; the disease is HIV-1 infection.