Chi-square test, independent sample t test and non-parametric test were performed on the clinicopathological parameters of the two groups, and the results showed that there were no significant differences in HBsAg, AFP, ALT, AST, ALP, GGT, TBIL, DBIL, IBIL, ALB, TG, PLT, tumor size, tumor type, nerve invasion, and NRAS, BRAF mutation status between the two groups (P > 0.05) (Supplementary Table 1). This evidence concerns the gene NRAS and neoplasm.