Now the question emerges as to whether PCOS presence leads to Peutz-Jegher or vice-versa; in other words, is hyperandrogenism inhibiting LKB1 by feedback mechanism or is LKB1 inhibition presence in Peutz-Jegher syndrome failing to suppress androgen levels, leading to PCOS? This evidence concerns the gene STK11 and Peutz-Jeghers syndrome.