Animal studies showed that soluble epoxide hydrolase inhibitor, 12-(3-adamantan-1-y1-ureido)-do-decanoic acid (AUDA), was found to attenuate angiotensin II-induced hypertension [19], and EPHX2 knockout mice exhibited lowered blood pressure and were immune from ventricular dysfunction [20]. The gene discussed is EPHX2; the disease is hypertensive disorder.