BCL6 and neoplasm: Furthermore, there exist controversies around the rationale and the impact of targeting BCL6 as a monotherapy due to the presence of high intra- and inter-tumor heterogeneity regarding type and number of oncogenic mutations [2, 3] and the possibility of oncogene addiction switching following BCL6 targeted therapies by reactivating BCL2-family dependent anti-apoptotic pathways [29].