Several known cancer-related genes including prolactin-inducing protein, Heat shock protein 40 homolog, chemokine (C-C motif) receptor 7, programmed cell death 4 as well as other genes like retinoblastoma1 (Rb), phosphate and tensin homolog (PTEN), early growth response 2 (Egr2), protocadherin 4, and RNA binding motif protein 4 displayed remarkably lower expression in the prostates of WT and LPB-Tag genotypes as compared to their corresponding CTRKO genotypes (For example, WT vs CTRKO; LPB-Tag vs LPB-TagCTRKO. The gene discussed is RBM4; the disease is cancer.