HMGCS2 and neoplasm: In particular, genes encoding HMG-CoA synthase, HMG-methyl CoA reductase, and steroyl CoA desaturase were highly up-regulated in the tumors of LPB-Tag mice but were underexpressed in the prostates of LPB-TagCTRKO as well as CTRKO genotypes, suggesting that CTR may be a key enhancer of tumor associated lipid metabolism and hypercholesterolemia.