PLK1 and Familial prostate cancer: Literature review was performed on these pathways, and 13 genes (RRM2, ORC6, CDC45, CDKN2A, E2F2, MYBL2, CCNB2, PLK1, FOXM1, CDC25C, PKMYT1, GTSE1, and CDC20) in nine correlated pathways (mitotic G1-G1/S phases, oncogene induced senescence, G2/M transition, mitotic G2-G2/M phases, cell cycle checkpoints, G2/M checkpoints, G1/S-specific transcription, G1/S transition, and G2/M DNA replication checkpoint) were finally identified and speculated to be potentially correlated with prostate cancer (Figure 6B) (Nakayama and Nakayama, 2006; Malumbres and Barbacid, 2009).