Specific markers to prospectively isolate intermediate steps within the stromal to adipocyte commitment axis have also recently been identified in mice by Ambrosi et al. Namely, a tri-potent bone/cartilage/adipocytic perivascular CD45−CD31−Sca1+CD24+ stem-cell like population, a CD45−CD31−Sca1+CD24− adipocytic progenitor population and a more mature CD45−CD31−Sca1−Zfp423+ BMAd precursor population were identified in the context of aging, high-fat diet (HFD) induced obesity and bone regeneration (5). This evidence concerns the gene CD24 and obesity disorder.