PGP and fleck corneal dystrophy: Further, the occurrence of pilocarpine-induced SE in MAM rats worsens the BBB damage and induces the up-regulation of the multidrug resistance P-glycoprotein 1 (P-gp) in the perivascular astrocytes (Marchi et al., 2006), similarly to what described in human brain specimens of FCD patients (Sisodiya et al., 1999; Sisodiya et al., 2001; Sisodiya et al., 2002).