TMT1B and adenocarcinoma: In order to understand the biological functions of METTL7B in the progression of lung cancer, loss of function lung cancer cell model was applied by using lung adenocarcinoma cell line A549 and PC-9 since METTL7B was up-regulated significantly in adenocarcinoma tumor but not in lung squamous carcinoma based on TCGA dataset (http://ualcan.path.uab.edu/index.html) (Supplementary Figure S1).