CCND1 and cancer: Here, our data shown that depletion of METTL7B caused markedly decreased of CCND1 and eventually arrested cancer cells in G0/G1 phase and inhibited cancer cell proliferation in vitro and in vivo. We did not observe significant enhancement of apoptosis in shMETTL7B treated cells (data not shown) indicating that cell cycle arrest is the main cause of proliferation inhibition in cancer cells.