PRRT2 and diabetes mellitus: DN, as a chronic complication of diabetes, is a main cause of end-stage kidney disease (Flyvbjerg, 2017; Zhang J. et al., 2018), which occurs in patients with DM, and reduced kidney function involved in hyperglycemia-induced renal hyper filtration and injury, AGE-induced increased OS, activated protein kinase C (PKC)-induced increased production of cytokines, chemokines, and different inflammatory and apoptotic signals (Bhattacharjee et al., 2016).