In summary, LDHJ improved cholestasis, downregulated CaSR expression and inhibited hepatocyte apoptosis in the young animal model with intrahepatic cholestasis through regulating the mitochondrial pathway and MAPK pathway, and further cell experiments show that one of the three active substances (forsythoside-A, emodin and chlorogenic acid) may be the inhibitors of CaSR. This evidence concerns the gene CASR and cholestasis.