For Thai patients, HLA-B*58:01 is strongly associated with allopurinol-induced SJS/TEN (odds ratio = 579.0; 95% CI: 29.5–11362.7; p-value < 0.001), DRESS (odds ratio = 430.3; 95% CI: 22.6–8958.9; p-value < 0.001), and MPE (odds ratio = 144.0; 95% CI: 13.9–1497.0; p-value < 0.001) (Sukasem et al., 2016). This evidence concerns the gene HLA-B and toxic epidermal necrolysis.