Specifically, the Class I PIK3 catalytic subunit p110δ has drawn attention for the genetic association to psychiatric disorders, increased expression in schizophrenia, autism and intellectual delay, as well as an emerging novel target for antipsychotic drug development (Marder et al., 2011; Law et al., 2012; Rico, 2012; Papaleo et al., 2016; Poopal et al., 2016; Coulter et al., 2017; Hood et al., 2019). Here, PIK3CD is linked to psychiatric disorder.