In another study examining the role of TDP-43 in synaptic loss, TDP-43 and perforant pathway synaptic loss were found to be the major contributors to dementia in the oldest-old (Robinson et al., 2014), and a trend between pTDP-43 pathology and synaptic loss in the frontal cortex of ALS cases was observed (Henstridge et al., 2018). Here, TARDBP is linked to amyotrophic lateral sclerosis.