Studies have shown that pathological TDP-43 was found to be increased in the motor cortex of Aβ1–42 lentivirus-transfected 3 × Tg-AD mice, and Aβ clearance prevented increased TDP-43, which suggested that TDP-43 aggregation may be triggered by Aβ (Herman et al., 2011). This evidence concerns the gene TARDBP and Alzheimer disease.